USE OF DOUBLE FIXED-DOSE COMBINATION OF OLMESARTAN AND AMLODOPINE VERSUS FIXED-DOSE COMBINATION OF LISINIPRIL AND AMLODOPINE IN UNCONTROLLED HYPERTENSIVE PATIENTS

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Fixed-dose combination Therapy in Hypertension: Focus on Fixed-dose combination of Amlodipine and Valsartan (exforge®)

Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...

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Efficacy and tolerability between an olmesartan/amlodipine fixed-dose combination and an amlodipine double dose in mild to moderate hypertension.

Fixed-dose combinations (FDCs) are one of the options for improving blood pressure (BP) goal attainment. We enrolled 141 patients and evaluated the efficacy and safety between a fixed dose of olmesartan/amlodipine (OA) and a double dose of amlodipine (DA) for treating mild to moderate hypertension after amlodipine monotherapy failure. After at least 2 weeks of monotherapy failure, the patients ...

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Effectiveness and tolerability of a fixed-dose combination of olmesartan and amlodipine in clinical practice

OBJECTIVES To assess the efficacy and tolerability of a fixed-dose combination of olmesartan and amlodipine in an unselected population of patients in primary care and to compare the results with recent randomized controlled trial evidence. METHODS A multicenter, noninterventional, noncontrolled observational study with 8241 hypertensive patients seen by 2187 physicians in daily practice. Blo...

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Safety and effectiveness of a fixed-dose combination of olmesartan, amlodipine, and hydrochlorothiazide in clinical practice

BACKGROUND Clinical trials indicate that the use of fixed-dose combinations (FDCs) is associated with a higher level of treatment adherence and prolonged blood pressure (BP) control. The aim of this study was to document the safety and effectiveness of the FDC olmesartan/amlodipine/hydrochlorothiazide in patients with essential hypertension in clinical practice. METHODS This multicenter, pros...

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Fixed Dose Combination and Disease Management

Fixed dose combinations (FDCs) are combinations of two or more active drugs in a single dosage form. It is the current hot topic of deliberations in the pharmaceutical industry, drug regulatory agency, and the pharmaceutical trade. Surprisingly, it is not so among the doctors who prescribe the medicines or the patients who consume. Basically, from one point of view it increases patient complian...

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ژورنال

عنوان ژورنال: Journal of Hypertension

سال: 2021

ISSN: 0263-6352,1473-5598

DOI: 10.1097/01.hjh.0000745844.63370.1b